Disulfides of the lutropin receptor.
نویسندگان
چکیده
منابع مشابه
The lutropin/choriogonadotropin receptor, a 2002 perspective.
Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in...
متن کاملMolecular basis of the regulation of the lutropin/choriogonadotropin receptor.
The studies summarized here clearly show that the phosphorylation of one or more serine residues (S635, S639, S649 and/or S652) present in the C-terminal tail of the LHR is necessary, but not sufficient, for the agonist-induced uncoupling of the LHR from adenylate cyclase and for the endocytosis of the agonist-receptor complex. Simultaneous mutation of these four serines to alanines decreases t...
متن کاملNa+ modulates the affinity of the lutropin/choriogonadotropin receptor.
The studies presented herein were designed to assess the effects of Na+ on the affinity of the lutropin/choriogonadotropin (LH/CG) receptor. We performed competition binding experiments in buffers containing NaCl or an isosmolar concentration of an appropriate Na+ substitute. The results presented show that Na+ decreases the affinity of LH, but not that of CG, in intact cells and membranes. In ...
متن کاملMacromolecular photoaffinity labeling of the lutropin receptor on granulosa cells.
Lutropin, a pituitary hormone, and human choriogonadotropin bind to the same receptors in the ovary and elicit identical responses. A photoactivable derivative of human choriogonadotropin was used to identify the lutropin receptor on porcine granulosa cells. The hormone was condensed with a heterobifunctional reagent, the N-hydroxysuccinimide ester of 4-azidobenzoylglycylglycine, and iodinated....
متن کاملDesensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein.
Purified rat Leydig tumour cells were pretreated with lutropin and the effect on the subsequent response to lutropin was determined. Maximal cyclic AMP production was achieved with the same concentration of lutropin in control and lutropin-pretreated cells; however, the maximum stimulated level in pretreated cells was only 30% of controls. The sensitivity to lutropin was decreased in lutropin-p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1986
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)38420-x